I have seen this conversation, and I think it is a little unnatural because of the pronoun 'I', am I right? Must it be 'me'?
Let's talk, you and me.
Thanks...
Since the contracted form "let's" represents "let us", and "us" is an object pronoun, and "you and ___" in your example is stating in more specific terms who "us" is, I would go stay with the object pronouns "you and me".