What is the difference in meaning if ...

[NewHopeR]

What is the difference in meaning if I substitute big word amalgamation with small word mixture?

Context:

A group of parapsychology sleuths accuse NASA of hiding evidence of aliens on the lunar surface -- wild tales that sound like an amalgamation of Hollywood sci-fi movies: "Apollo 18," "Minority Report" and "Alien."

Transception Incorporated, self-described as an Austin, Tex., based psychic R&D operation, sent a letter to NASA Administrator Charles Bolden that nominates the Apollo 16 crew for the Congressional Space Medal of Honor.

[BobSmith]

[not a teacher]

Personally, it doesn't change the meaning at all. Also, I might use "amalgam" over "amalgamation" here.