D and I

[kahhong]

Hello there, Despite of and inspite of are thhe same?

[Casiopea]

despite, not *despite of

despite something
despite + -ing
despite the fact that

in spite of, not *inspite of
in spite of has the same meaning as despite.

in spite of something
in spite of + -ing
in spite of the fact that

Note, despite is preferred in written English. The reason being, its origin:

Etymology
spite comes from the word despite. It's a shortened form.
in despite of became in spite of.