Proper Usage

[sploke]

Appreciate if someone can tell me how and when to use these words, using examples where possible:
nonetheless; nevertheless; despite; in spite of
thanks

[Tdol]

Nonetheless/neverthelss contrast sentences:

I was exhausted. Nevertheless, I worked all night.

Despite/in spite of go with a noun phrase:
He did it despite my advice.

[sploke]

Tks Tdol. But does that mean that the two pairs of words/phrase are interchangeable in usage?

[Tdol]

Yes, basically, though in spite of and nonetheless are less commonly used.