Run Interference or Interfere?

[sonichka]

“let me run interference with her tonight” Could "run interference" be replaced by "interfere"? “let me interfere with her tonight”

[Soup]

“let me run interference with her tonight” Could "run interference" be replaced by "interfere"? “let me interfere with her tonight”

It depends on what you want it to mean. The two phrases mean different things:

run interference (American) to help someone achieve something by dealing with the people or problems that might prevent them from doing so (usually + for ) When it comes to finding a hotel room, you'll be glad to have a tourist guide run interference for you.

interfere in somethingto meddle in something; to become involved in someone else's business. Don't interfere in my business! Are you interfering in this matter again?

interfere with someone or something
to meddle with something or someone's affairs. Please do not interfere with us. Are you interfering with my project?

Source interfere - Idioms - by the Free Dictionary, Thesaurus and Encyclopedia.