I've got a question: do the expressions "what's the matter with you/what's wrong with you?" mean the same as "what's the matter/what's wrong?"?
I have the feeling that the 1st expressions are more ironic, am I right?
The first, "......matter with you" and ".........wrong with you" are more personal and direct and could be considered somewhat argumentative or, as you say, sarcastic. The second examples "what's the matter"/"what's wrong" are less direct and used most often to inquire about a problem or situation that the speaker has noticed to be unusual behavior or reaction by the listener.