There is an idiomatic phrase in English about following the path (line) of least resistance. It usually means using the easiest possible method to accomplish a task while disregarding the quality of the results. Scientifically, liquids follow the line of least resistance when they flow downhill. The statement you quoted is a clever play on words based on the similarity in sound of persistance and resistance, but it means that people who are not persistant will fail.
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