Okay , I am aware of the formal use of the greeting phrase "how do you do?", which should be replied with the same phrase. However, can the phrase "how do you do?" by used in the English language to be synonymous with "how are you?" ?.
how do you do , we use it when we meet somebody for the first time , but on subsequent meeting , it's better to say ' how are you '
so I dont think ' how do you do' is synonymous with "how are you'?