Let's treat him with not medicine.
I have seen in a TV-series. Is that a good usage?
It sounds like the person was trying to make a play with words, but without context, I can't tell. It could just be bad English.
Sounds like something you'd hear on House, where they are always arguing about what to do and how to proceed.
I'm not a teacher, but I write for a living. Please don't ask me about 2nd conditionals, but I'm a safe bet for what reads well in (American) English.