Let's say Alice lived in San Francisco. Then she went to a hotel in San Francisco to visit some friends. Then she has not be seen since, so she was last seen at the hotel. I thought up a few ways to describe this scenario:

"Alice went missing at/in/from/out of San Francisco."
"Alice went missing at/in/from/out of a hotel."

Which of "at", "in", "from", "out of" should be used in these two sentences?