She couldn't be depended upon because of her health problems.
What does (depended upon) mean?
Does it have the same meaning with (depended on)?
Thanks in advance
Yes, "depend upon" is the same as "depend on"; just like "based upon" = "based on", etc.
Now, to rephrase the quoted sentence, I'd propose something like this:
"One couldn't rely on her because of her health problems."