welcome in the forum.
The use of with and about depends on the context. Usually every verb/expression has its own preposition.
I'll think about that.
What's wrong with you?
Sometimes more than one preposition is possible but it always depends on the context. Here no one can explain to you how these preposition are used in every sentence possible.
Provide a particular situation and you'll find somebody who can help you.
P.s: I'm not a teacher.