Question #1Originally Posted by amigo
When someone is out of it it means the person can't function normally because of drug or alcohol intoxication. It also means a person might be VERY tired/exhausted or feeling "not with it" because he/she is sick.
You can say the same about an animal when he is not feeling well.
about Ryan Seacrest ... I am assuming that "Ryan out" means "you are off the air", "you're done", "cut" or something like that.