It stands on the Rhine, just above where the Rhine meets the Main, at the southern tip of the most picturesque stretch of the river.
Just below the industrial heartland.
That means to the North and to the East, doesn’t it?
By the way, what does “tip” mean in this case? Does it mean “end” here? I understand that the Rhine flows from the South to the North at that place, and that very part of the river is the most beautiful. And on the edge of this beautiful part, that is in the southernmost part of this stretch of the river, there is a town or city or something. And near it there is a bend in the river, or the river ceases to be picturesque a little bit further.