She describes prolonged latency, which began during her second pregnancy and which persists.
No need for a pause, so no comma. There is a unity between 'which began' and 'which persists', as opposed to: 'which began with all the hopes of the nation riding on its wake, and all the determination that he, as an individual, a majority of one, could muster to stem....'
This began in 1997, when, postpartum, she developed irritability, mood swings, tearfulness, anhedonia, feelings of being overwhelmed, guilt, and increased fatigue.
The emphasis is on what developed, not on 'when she was postpartum'.
At this time, she describes multiple acute stressors subsequent to her husband's losing his job.
Subsequently, they moved to Denver, where he is currently employed with Janus Investments.
Individual and Couples Therapy
(Trust me - I was a therapist.)