You and I are playing.
Use "I", not "me" because "me" is an object pronoun, and "I" is a subject pronoun.
When "I" is part of a double subject, "I" usually is second, or last if there are three or more subjects.
Here's where "you and me" is correct.
Let's just keep this between you and me. It'll be our secret.
Use "me" because it comes after a preposition. It's the object of a preposition.
Student or Learner