1 = try again, using 'caused to <NP>'; 'even the <superlative-adj.>' is a fixed expression. The writer was overwhelmed by his own rhetorical flourish: what he meant was 'even the most advanced' - so I'm not surprised that you found this hard to make sense of! )
2 This expression is based on a quotation from Paradise Lost - Wikipedia, the free encyclopedia - 'All Hell broke loose'. Milton meant Hell as a real place (real, that it, in his allegory); but in current usage it just means 'everything went badly wrong'.
Student or Learner