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    • Member Info
      • Native Language:
      • Chinese
      • Home Country:
      • Taiwan
      • Current Location:
      • Taiwan

    • Join Date: Dec 2003
    • Posts: 514
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    Dear Teachers,

    I read this from 29 Gifts by Cami Walker:

    "In the case of Multiple sclerosis, the immune system attacks the myelin, a protective fatty layer surrounding the nerves. Think of it as insulation that keeps the nerves firing smoothly. ... I imagine little holes being eaten in my nerve linings that leave areas of raw, exposed nerve prone to misfiring."

    What do "fire" and "misfre" mean in this context?

    • Join Date: Dec 2009
    • Posts: 576
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    Re: fire/misfire

    (Not a teacher)


    27. to discharge (a gun).
    to project (a bullet or the like) by or as if by discharging from a gun.

    Discharge is probably a more appropriate word, but 'fire' is the word used to describe the stimulation of a nerve in the body to send it's action potential (electrical signal). Misfire is the opposite, i.e. a nerve which doesn't release it's action potential (or in the case of Multiple Sclerosis, releases the signal, but it fails to reach the nerve ending.)


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