Student or Learner
Is it correct to use the following sentence in the reply of a mail?
"In the wake of your mail, I want to discuss........"
'in the wake of your mail' doesn't work, at least in British English IMO.
I would say:
In response to your email of [date], I would like to discuss...
In light of your recent email, I would like to discuss...
Further to your recent email, I want to discuss...
'In the wake' applies only to two successive happenings or events. It would be weird to apply it to a mail.
In a less frivolous vein, you could get rid of the prepositional phrase altogether, and say 'Your mail raises some issues/opportunities/problems... <any appropriate abstract noun> that I'd like to discuss.'