Student or Learner
We may say "A scientific brake-through brought about many changes".
Can we say "Drama first brought about in Italy"? Is it always transative?
Yes - 'bring about' is always transitive. In your 'Italy' sentence you could use various intransitive verbs: 'spring up'/'emerge'/'come to light'... Or you could make Italy the subject: 'Italy saw the emergence...'/'Italy was the source....' [Of course, it wasn't, but that would be a way to express the idea.]
(It's 'break-through'. [But with the same pronunciation: /breɪk/ .])