I think many speakers expand 'we' to 'you and me' (= us) instead of the more correct 'you and I'. It is normally not acceptable to have 'me' as a subject pronoun.
According to some grammars, 'It's me' is ungrammatical, but how many English speakers say 'It is I'??
Combinations of personal pronouns with 'you' can confuse, because 'you' can be both nominative (subjective) and accusative (objective).
There are of course situations where 'you and me' is correct, 'He teaches you and me'. 'me' is also used as a subject in constructions with verbal nouns like: 'Me going to Irak was a surprise', where the nominative pronoun (I) would sound wrong.
I wonder what drove people to give themselves two pronouns? 'I' and 'me' are one and the same person. The roots of the distinction are very old. Chinese makes no such distinction, with no loss of clarity. A dative form of 'me' is found in 'Mir ist kalt' (= Ich bin kalt.), and is, at least syntactically, the subject.