Although it's not used frequently in BrE, I would have thought it would be possible for someone to say "Payback's a bitch" after they have been subjected to some kind of revenge attack.
Example:
A man has an affair and his wife finds out. She is very angry about the affair and decides to cut up all his clothes and pour pink paint all over his car while he's at work.
He comes home from work and discovers what she has done. He calls a friend and says "Oh my god! She's cut up all my clothes and ruined my car as revenge for the fact that I slept with that other woman. Wow. Payback's a bitch!"
In that example, "bitch" would mean "a terrible thing" so he's saying that the revenge that has been carried out on him is a terrible thing.