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    #1

    What does "the two arms" mean here? Two groups?

    Context:

    Patients and Methods
    Eligible patients were randomly assigned 2:1 to receive vandetanib 300 mg/d or placebo until disease progression or unacceptable toxicity. The primary objective was to compare the outcomes between the two arms with respect to overall survival.

  1. bhaisahab's Avatar
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    #2

    Re: What does "the two arms" mean here? Two groups?

    Quote Originally Posted by NewHopeR View Post
    Context:

    Patients and Methods
    Eligible patients were randomly assigned 2:1 to receive vandetanib 300 mg/d or placebo until disease progression or unacceptable toxicity. The primary objective was to compare the outcomes between the two arms with respect to overall survival.
    It would seem to mean that.

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    #3

    Re: What does "the two arms" mean here? Two groups?

    Quote Originally Posted by bhaisahab View Post
    It would seem to mean that.
    Thank you.

    And then the author also used "the cohorts" to refer to "the two groups"?

    Results Overall, 924 patients received vandetanib (n = 617) or placebo (n = 307). No significant increase in overall survival was detected in the vandetanib cohort compared with placebo (hazard ratio = 0.95; 95.2% CI, 0.81 to 1.11; P = .527); median overall survival was 8.5 months versus 7.8 months for vandetanib and placebo patients, respectively. Statistically significant advantages favoring vandetanib were observed for progression-free survival (hazard ratio = 0.63; P < .001) and objective response rate (2.6% v 0.7%; P = .028). Postprogression therapy was balanced across the cohorts in both number and type. Adverse events were generally consistent with previous NSCLC studies of vandetanib 300 mg; common events occurring with a greater frequency in the vandetanib arm versus placebo included diarrhea (46% v 11%), rash (42% v 11%), and hypertension (26% v 3%).

  2. BobK's Avatar
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    #4

    Re: What does "the two arms" mean here? Two groups?

    Quote Originally Posted by NewHopeR View Post
    Thank you.

    And then the author also used "the cohorts" to refer to "the two groups"?
    That's the more common word, in statistical texts. I wonder why they used 'arm' previously...

    b

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    #5

    Re: What does "the two arms" mean here? Two groups?

    I did not know this definition of cohort:

    co·hort

    noun \ˈkō-ˌhȯrt\

    Definition of COHORT

    1
    d : a group of individuals having a statistical factor (as age or class membership) in common in a demographic study <a cohort of premedical students>
    - Cohorts - Definition and More from the Free Merriam-Webster Dictionary

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