with not

[aysaa]

Hi,

Let's treat him with not medicine.

I have seen in a TV-series. Is that a good usage?

[Barb_D]

No.

It sounds like the person was trying to make a play with words, but without context, I can't tell. It could just be bad English.

Sounds like something you'd hear on House, where they are always arguing about what to do and how to proceed.