What does "wild card" mean here? And what "that" refers to here?

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NewHopeR

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[h=3]Wild card[/h]The wild card is lung cancer, cases of which will vary according to how strictly anti-smoking laws are enforced as countries become more affluent. Lung cancer has soared in China, for example, and the government introduced an initiative to ban smoking in some public venues last year.
Bray says that forewarned of the problems, governments can plan to head them off. "Hopefully, the awareness of cancer is increasing substantially, and this study is part of that," he says.
 

Barb_D

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Re: What does "wild card" mean here? And what "that" refers to here?

The thing they can't plan. They don't know what the rates will be, perhaps.
 
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