1 - it works, after a fashion, but it's not nearly as good as 2. Being 'bothersome' usually involves being a bother either several times or continually.
3 Yes, you can use 'caused' in that case (but you can't use 'breakup' as a verb - it's 'break up'). Alternatively make it a noun: 'My comment had caused the breakup/divorce.'
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