In your sentence, only with works.

Student or Learner
Linda felt sick _________ tiredness, and therefore she had a break.
A. with B. from
As shown in a dictionary, sick is followed by "with" or "of".
Are both answers correct?
Thanks for your advice!
Jason
In your sentence, only with works.
...because when 'sick' is followed immediately by 'of' it doesn't mean what you want it to mean. It means 'fed up with'. 'I'm sick of politicians fiddling their expenses' doesn't refer to any physical malady.
In the case of your sentence, 'sick with' doesn't sound to me natural. I would say - and expect to hear - something like 'I am so tired I feel sick'. But if those two answers are the only available ones (in a rather dubious test) 'with' is the only possibility.
b
Just a note: your title said you were querying whether to use "with" or "from", but your actual post asked about "with" or "of".
Remember - if you don't use correct capitalisation, punctuation and spacing, anything you write will be incorrect.
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