Student or Learner
I want to know if the sentence below makes any sense?
Of this method of characterizing the size of active sites have been attempted with varying success
If you remove the first word, change "have" and perhaps add a couple of words towards the end of the sentence, it stands a chance of being intelligible. At the moment, it means nothing.
Remember - if you don't use correct capitalisation, punctuation and spacing, anything you write will be incorrect.