In AmE, "How's every little thing?" is fairly common.... Often it is asked when two friends meet who haven't seen each other for a long time. When someone asks "How's every little thing?" it indicates that they're looking for a more detailed response than "Fine" (the traditional response to "How are you?"). They don't necessarily want a point-by-point recap of your life, but just a general update to get a conversation going.
For example:
Bob: "Fred! I haven't seen you in ages! Since you moved to Los Angeles for that new job, in fact."
Fred: "Yes, that was almost six years ago. I've moved back here now, working for Acme again."
Bob: "Well, it's great to see you. How's every little thing?"
Fred: "Oh, just fine, can't complain. My oldest son graduated from high school and stayed out West to attend U.C.L.A. My daughter just got her driver's license, so I promised her I'd help her buy a car after we got settled in here."
Bob: "Wow, they sure grow up fast, don't they? Where are you living, we've got to get together real soon...."