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  1. #1

    be constructed that

    Could you tell me what “constructed” means in this sentence?
    In this study, chimeric viruses were constructed that contained genes from both ONNV (o'nyong nyong virus) and CHIKV (chikungunya virus).
    If you need the context, the following is the whole abstract of the article.

    Determinants of vector specificity of o'nyong nyong and chikungunya viruses in Anopheles and Aedes mosquitoes.

    Vanlandingham DL, Tsetsarkin K, Klingler KA, Hong C, McElroy KL, Lehane MJ, Higgs S.

    Department of Pathology, University of Texas Medical Branch, Galveston 77555-0609, USA.

    The alphaviruses o'nyong nyong virus (ONNV) and chikungunya virus (CHIKV) provide a unique system to study the viral genes involved in vector specificity. ONNV infects both anopheline and culicine mosquitoes, whereas CHIKV infects only culicine mosquitoes. In this study, chimeric viruses were constructed that contained genes from both ONNV and CHIKV. These chimeras and previously described full-length infectious clones of ONNV and CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes. Virus derived from the infectious clones of ONNV and CHIKV retained the vector specificity of the parental viruses. All six of the chimeras were found to infect Ae. aegypti mosquitoes at high rates but only the chimera containing viral genes encoding all of the structural proteins of ONNV was able to infect An. gambiae mosquitoes. These data indicate that all of the viral structural proteins are necessary for ONNV to infect An. gambiae mosquitoes.

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    #2

    Re: be constructed that

    Wouldn't it mean that they literally built the viruses artificially? I know that recently they made the Spanish Flu virus in a laboratory.

  2. #3

    Re: be constructed that

    chimeric viruses were constructed that contained genes from both ONNV and CHIKV. = chimeric viruses that contained genes from both ONNV and CHIKV were constructed?

    If so, that explains!
    Thank you very much!!!

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    #4

    Re: be constructed that

    I presume that they assembled the viruses from those sources of genes- it's amazing what scientists can do nowadays.

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