Why will I get odd looks if I ask where I can buy the "spirits"? If I ask "liquors", will I get odd looks as well?
Because as we've explained, 'spirits' isn't used colloquially. It'd be like asking somebody where you could find some 'cuisine'. They are literary terms only.
And actually, there are a few certain parts of the US where it would get you a funny look to ask for any kind of alcohol. Certain parts of the US are what we call 'dry', meaning all sales of alcohol are legally prohibited. Of course it doesn't stop people from making their own and selling it illegally, which is referred to as moonshining (the distillation) and bootlegging (the transportation). However, it's all hush-hush, not something you're go about asking perfect strangers.
Other parts of the US it may not actually be illegal, but the general population frowns upon consumption for religious reasons, so again, if you wanted some, you'd have to make discreet inquiries.
And of course, from about 1920 to 1933, there was a national law against making, distributing, and selling ALL alcohol throughout the entire United States, during a dark period known as Prohibition. We even made the 18th Amendment to our Constitution making alcohol illegal. Fortunately, we came to our collective senses and repealed it with the 21st Amendment.
Prior to prohibition, some states were already 'dry'. My state of Kansas was the first to abolish alcohol, in 1881. (Fortunately, I wasn't born for almost another hundred years. )
During that period of sobriety we also passed an Amendment allowing women to vote. I'm not sure if there's
a connection there or not.