Yes, I suppose so.
Student or Learner
Can you blow an enemy drone the f..k out of the sky?
Only if you feel it necessary to use a gratuitous obscenity.
In formal writing, delete 'the f..k'.
I'm not sure that "blow it out of the sky" is particularly formal either.
Shot it down, perhaps.
I'm not a teacher, but I write for a living. Please don't ask me about 2nd conditionals, but I'm a safe bet for what reads well in (American) English.
You can do pretty much anything you want with the word- it's nothing if not flexible.