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    #1

    (GMP) challenge stock

    It appears that both challenge and stock are nouns here. Google search doesn't offer me the clue of what is "challenge stock". What does it mean? Does it mean "challenging stock" (extremly large amount of products in stock)?

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    CHIMs, by contrast, require infecting healthy persons with a well-characterized microorganism in order to study pathogenesis, characterize the immune response, and elucidate the efficacy of vaccines or therapeutics. CHIMs can minimize the uncertainty about exposure or disease acquisition inherent in field trials, thereby reducing the number of participants needed to establish the desired end point (e.g., sterilizing immunity, reduced susceptibility to infection, or attenuated disease). Researchers in these studies must ensure that procedures minimizing participant, staff, and community risk are strictly enforced and that CHIMs are rigorously designed to provide scientifically robust data. A key requirement is the preparation of a Good Manufacturing Practice (GMP) challenge stock with demonstrated stability and consistent infectivity. This process may take as little as a month for a well-characterized pathogen or as much as a year if attenuating mutations are introduced to minimize participant risk.


    Source: New England Journal of Medicine
    https://www.nejm.org/doi/full/10.105...=featured_home

  2. Charlie Bernstein's Avatar
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    #2

    Re: (GMP) challenge stock

    Quote Originally Posted by GoodTaste View Post
    It appears that both challenge and stock are nouns here. Google search doesn't offer me the clue of what is "challenge stock" is. What does it mean? Does it mean "challenging stock" (extremly large amount of products in stock)?

    No. That wouldn't make sense.


    ===================

    CHIMs, by contrast, require infecting healthy persons with a well-characterized microorganism in order to study pathogenesis, characterize the immune response, and elucidate the efficacy of vaccines or therapeutics. CHIMs can minimize the uncertainty about exposure or disease acquisition inherent in field trials, thereby reducing the number of participants needed to establish the desired end point (e.g., sterilizing immunity, reduced susceptibility to infection, or attenuated disease). Researchers in these studies must ensure that procedures minimizing participant, staff, and community risk are strictly enforced and that CHIMs are rigorously designed to provide scientifically robust data. A key requirement is the preparation of a Good Manufacturing Practice (GMP) challenge stock with demonstrated stability and consistent infectivity. This process may take as little as a month for a well-characterized pathogen or as much as a year if attenuating mutations are introduced to minimize participant risk.

    Source: New England Journal of Medicine
    https://www.nejm.org/doi/full/10.105...=featured_home
    I Googled gmp challenge stock, and there were several links. Apparently, stock means virus supply. A virus used in part of the trials is call a challenge stock.

    Here's one of the links that uses the term:

    challenge stock

    You might try Google again to see what else you can find.
    I'm not a teacher. I speak American English. I've tutored writing at the University of Southern Maine and have done a good deal of copy editing and writing, occasionally for publication.

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