To make is usually followed by a noun. You can make a cake, make a noise, make a mess, make a model, make a mistake, make a friend, make peace, make trouble. It means that something is being created/constructed.
To do is "to carry out or perform an action" - but it's most often used in question or negative forms, and usually do goes together with another verb.
Does that make sense? I don't know a very good way to explain this.
do - OneLook Dictionary Search