Results 1 to 5 of 5

    • Join Date: Apr 2005
    • Posts: 50
    #1

    What is a "upstream" culprit?

    Hello, everyone.

    The article below is about theory of Alzheimer's disease.

    For more than 20 years, the leading theory has held that sticky blobs in the brain called amyloid plaques cause Alzheimer's. Because that idea has numerous problems, doubters argued that the plaques might be innocent bystanders to the real, "upstream" culprit.

    What I understood was that amyloid plaques that has been considered as a culprit of Alzheimer's but it was not. There is another cause(culprit).

    But I have to understand the meaning of "upstream" in this sentence.
    Could anyone give me other word which has the same meaning of "upstream" in the paragraph?

    Thank you,
    Higurashi

    • Member Info
      • Native Language:
      • British English
      • Home Country:
      • UK
      • Current Location:
      • Laos

    • Join Date: Nov 2002
    • Posts: 57,845
    #2

    Re: What is a "upstream" culprit?

    The real culprit is at a higher level, causing a problem that filters down to the plaques.


    • Join Date: Apr 2005
    • Posts: 50
    #3

    Re: What is a "upstream" culprit?

    Thank you, Tdol-san!

    Higurashi

    • Member Info
      • Native Language:
      • British English
      • Home Country:
      • UK
      • Current Location:
      • Laos

    • Join Date: Nov 2002
    • Posts: 57,845
    #4

    Re: What is a "upstream" culprit?

    You're welcome, Higurashi-san.

  1. MikeNewYork's Avatar
    • Member Info
      • Native Language:
      • American English
      • Home Country:
      • United States
      • Current Location:
      • United States

    • Join Date: Nov 2002
    • Posts: 24,983
    #5

    Re: What is a "upstream" culprit?

    Quote Originally Posted by higurashi View Post
    Hello, everyone.

    The article below is about theory of Alzheimer's disease.

    For more than 20 years, the leading theory has held that sticky blobs in the brain called amyloid plaques cause Alzheimer's. Because that idea has numerous problems, doubters argued that the plaques might be innocent bystanders to the real, "upstream" culprit.

    What I understood was that amyloid plaques that has been considered as a culprit of Alzheimer's but it was not. There is another cause(culprit).

    But I have to understand the meaning of "upstream" in this sentence.
    Could anyone give me other word which has the same meaning of "upstream" in the paragraph?

    Thank you,
    Higurashi
    Many people now believe that the real problem in Alzheimer's Disease causes damage to the brain, and the amyloid deposits are simply the body's way of filling in the holes caused by the real problem.

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •