No. The definite article is used only to refer to a specific instrument, or to that category of instrument in a general sense.
The flute is on the table. (A specific flute)
The flute is a woodwind instrument. (General)
Otherwise, you can use an indefinite article, or no article at all.
There is a flute on the table. (No particular flute, just a flute)
The sound of flutes could be heard. (Some flutes or other)