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Researches from the Institute for Horticulture in collaboration with researches from the Institute for Parasitology elaborate environmentally- friendly and energy-savings methods of plant protection (especially for berries and fruits). In the results of long- term investigations, biological agents that control most harmful pathogens (nematodes, fungi, viruses, mites and other arthropods) were revealed. It was demonstrated that strains of antagonistic bacteria and fungi with with different mechanisms of action, their mixtures and biopesticides , predatory mites and Hemiptera, entomopathogenic nematodes effectively suppress complex of most harmful pathogens and productivity of fruits, potatoes and other vegetables increased as the result. This makes possible to start ecologically- safe production of main crops in the 21st centuary.