Student or Learner
Is a comma needed in front of "and 'big sister'"?
Your teacher, friend, and 'big sister'?
['Big sister' is used in a non-literal sense.]
Why would you want to?
I should have been less lazy, and given the second reason - the 'avoiding ambiguity' as in, "To my parents, Ayn Rand and God", but I couldn't think up an example at the time.
So the real answer is that it's not necessary in Mister Nutty's case, but occasionally it is.
I rarely use a comma before 'and' unless it is absolutely necessary to avoid ambiguity, in my English education we would have been beaten to death at the very least for such a thing.