at 0 hours and 24 hours?

[ostap77]

"[FONT=&quot]Rats were administered gavage doses of 250, 500, and 1,000 mg/kg/day flurbiprofen at[/FONT][FONT=&quot] 0 hours and 24 hours[/FONT]." I've been trying to undestand the meaning of the sentence but nothing comes to mind. What's "at 0 hours and 24 hours" mean?

 

[SoothingDave]

They seem to mean the times of day. Except, of course, that 0 and 24 are the same time of day. So, it doesn't make sense to me.

 

[charliedeut]

Although I'm not an expert, it suggests me that they were given a first dose (which was considered the beginning of the experiment) and another dose 24 hours (ie a day) later.

 

[SoothingDave]

Although I'm not an expert, it suggests me that they were given a first dose (which was considered the beginning of the experiment) and another dose 24 hours (ie a day) later.

I would think that as well, but it says the doses were mg/kg/day. Which would imply a daily schedule. Something still doesn't make sense. If I give a dose now and one in 24 hours, then I am basically giving one dose/day.

 

[charliedeut]

I would think that as well, but it says the doses were mg/kg/day. Which would imply a daily schedule. Something still doesn't make sense. If I give a dose now and one in 24 hours, then I am basically giving one dose/day.

Of course, there's always the possibility of a misprint of the numbers, so the hours would be 10 and 24. Maybe the OP could clarify this.

 

[MikeNewYork]

This is common in experimental design. The drugs were given one day and then repeated at the same time on day 2.