[Vocabulary] for the most part & by and large

[eggcracker]

Are 'for the most part' and 'by and large' interchangeable in the following sentence without sounding awkward and making difference?
"The journalists at the Guardian have, 'for the most part', supported the system."

 

[bhaisahab]

Are 'for the most part' and 'by and large' interchangeable in the following sentence without sounding awkward and making difference?
"The journalists at the Guardian have, 'for the most part', supported the system."

Yes.