The situation is like this:
A person is seriously trying to explain something to his boss; and his co-worker frequently interrupts and says something else to the boss. Now, the first person says the following to his co-worker:
1. Don't speak in the middle.
2. Don't speak in the middle of my talk with the boss.
3. Don't speak in between (my talk with the boss).
4. Don't interrupt my talk with the boss.
5. Don't interrupt/disturb while I am talking to the boss.
Which one is natural English?
Thanks.