The prime minister opened his speech

[Bassim]

I am wondering if my sentence sounds natural.

The prime minister opened his speech with some self-deprecating remarks which drew laughs and applause from the audience.

 

[GoesStation]

The noun is applause.​ Correct that and the sentence will be natural.

 

[emsr2d2]

I am wondering if my sentence sounds natural.

The prime minister opened his speech with some self-deprecating remarks which drew laughs and [STRIKE]applauds[/STRIKE] applause from the audience.

See above.

"Applauds" is the third person singular form of the verb "to applaud". "Applause" is the associated noun.