She gathered her bags and hurried down/up/along the street.
Can all three prepositions be used here without difference in meaning?
Thank you in advance.
In most cases, yes. If the street is on a big hill, then no, "up" and "down" will be different, of course.
I'm not a teacher, but I write for a living. Please don't ask me about 2nd conditionals, but I'm a safe bet for what reads well in (American) English.