In English "how?" can have two meanings: 1. "in what manner?" and 2. "what is the state of?"
'How' has rather more than two meanings: how - Dictionary definition and pronunciation - Yahoo! Education
Is then the title of this thread quite beside or irrelevant to its "entrails'

as it only addresses the issue of which particular words it is customary or common to use in a given situation rather than (as I meant it) the issue of the adjective "good" being used ungrammatically?
To many speakers of BrE,especially older ones, 'I am good' is still not a natural answer to the question 'How are you?' That does not make in necessarily ungrammatical.
"Is your wife good?" sounds to me as "Does your wife have a good heart?" (figuratively, not medically).
Now, were we to employ the meaning of "good" discussed in this thread, the question "is your wife good?" could be interpreted as "what is the state of your wife's health or mood or...?".
I would find that a very strange question. However, I suspect that many other native speakers might find it acceptable in the interpretation you suggest.
How would you interpret this question: "is your dog good?" asked by a guest? Would you answer:
"Oh, no worries, it won't bit
e you".
.....or
....."Yes, it is fine, maybe a bit underweight".
Is this ambiguity likely to take place in reality or is it only the product of my imagination?
For me, only the first interpretation works, but I am an older speaker of BrE.