GoodTaste
Key Member
- Joined
- Feb 19, 2016
- Member Type
- Student or Learner
- Native Language
- Chinese
- Home Country
- China
- Current Location
- China
Does "mediate" here mean "influence"?
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Moved to metastasize by gut microbiota
Bacterial dysbiosis in the gut, particularly an increase in Fusobacterium nucleatum, is associated with colorectal cancer (CRC). Casasanta et al. found that CRC cell–resident F. nucleatum promotes proinflammatory cytokine secretion that stimulates tumor cell migration and invasion. Gene deletion revealed that F. nucleatum infection of HCT116 CRC cells required a membrane adhesin protein that did not mediate bacterial infection of immune cells. Infected CRC cells secreted the cytokines IL-8 and CXCL1 that promoted the invasive motility of infected and noninfected cells. The findings suggest that preventing F. nucleatum invasion of tumor cells may reduce bacterial-associated gut inflammation and metastatic progression in CRC patients.
Source: Science Signaling 21 Jul 2020
Fusobacterium nucleatum[FONT="] host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration[/FONT]
https://stke.sciencemag.org/content/13/641/eaba9157
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Moved to metastasize by gut microbiota
Bacterial dysbiosis in the gut, particularly an increase in Fusobacterium nucleatum, is associated with colorectal cancer (CRC). Casasanta et al. found that CRC cell–resident F. nucleatum promotes proinflammatory cytokine secretion that stimulates tumor cell migration and invasion. Gene deletion revealed that F. nucleatum infection of HCT116 CRC cells required a membrane adhesin protein that did not mediate bacterial infection of immune cells. Infected CRC cells secreted the cytokines IL-8 and CXCL1 that promoted the invasive motility of infected and noninfected cells. The findings suggest that preventing F. nucleatum invasion of tumor cells may reduce bacterial-associated gut inflammation and metastatic progression in CRC patients.
Source: Science Signaling 21 Jul 2020
Fusobacterium nucleatum[FONT="] host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration[/FONT]
https://stke.sciencemag.org/content/13/641/eaba9157
