Escape from recognition of SARS-CoV-2 Beta variant spike epitopes

[GoodTaste]

Escape from recognition of SARS-CoV-2 Beta variant spike epitopes but overall preservation of T cell immunity​

SARS-CoV-2 variants have emerged that escape neutralization and potentially impact vaccine efficacy. T cell responses play a role in protection from reinfection and severe disease, but the potential for spike mutations to affect T cell immunity is incompletely understood. We assessed neutralizing antibody and T cell responses in 44 South African COVID-19 patients infected either with the Beta variant (dominant from November 2020 to May 2021) or infected prior to its emergence (first wave, Wuhan strain), to provide an overall measure of immune evasion.
Source: Science

I understand "Escape from recognition of SARS-CoV-2 Beta variant spike epitopes" as "Beta variant's escape from neutralizing antibody's recognition of the Beta variant spike epitopes", do you agree?
I'm sorry the question is a bit professional.

 

[Tarheel]

I think you are biting off more than you can chew.

**variants
**antibodies

Your explanation is confusing.

 

[probus]

Escape from recognition of SARS-CoV-2 Beta variant spike epitopes but overall preservation of T cell immunity​

SARS-CoV-2 variants have emerged that escape neutralization and potentially impact vaccine efficacy. T cell responses play a role in protection from reinfection and severe disease, but the potential for spike mutations to affect T cell immunity is incompletely understood. We assessed neutralizing antibody and T cell responses in 44 South African COVID-19 patients infected either with the Beta variant (dominant from November 2020 to May 2021) or infected prior to its emergence (first wave, Wuhan strain), to provide an overall measure of immune evasion.
Source: Science

I understand "Escape from recognition of SARS-CoV-2 Beta variant spike epitopes" as "Beta variant's escape from neutralizing antibody's recognition of the Beta variant spike epitopes", do you agree?
I'm sorry the question is a bit professional.

I think you are right. The epitope is the part of a molecule that an antibody attaches to. Failure to recognize the epitope means that the immune response fails completely because our antibodies cannot attach to the pathogen to neutralize it.

 

[Tdol]

I think the abstract suggests the variant can get past the antibodies. The T cells are a different matter and not fully understood, but seem to be tougher to fool. (Not a scientist)