GoodTaste
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- Feb 19, 2016
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Does the word "relevant" here be replaced by "related"? The latter appears to be a bit informal and cannot do the job. I am not sure. Dictionaries only give me a vague clue.
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Controlled human infection models (CHIMs) have been proposed as a strategy for accelerating SARS-CoV-2 vaccine development. Commentaries have focused on the ethical considerations raised by such models, noting their societal benefits and articulating a range of opinions regarding whether the risk is justified.1-3 The controversy they consider hinges on assumptions about the risk posed by purposeful infection (challenge) of humans with SARS-CoV-2 in a world that lacks a reliable treatment for Covid-19. Both the public health imperative that drives the push for a SARS-CoV-2 CHIM and the demand that the risk be justifiable require a model capable of addressing meritorious questions and delivering scientifically sound answers. On behalf of the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group, we have focused on the practical considerations relevant to the development of a SARS-CoV-2 CHIM and the prerequisites for using such a model.
Source: New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMp2020076?query=featured_home
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Controlled human infection models (CHIMs) have been proposed as a strategy for accelerating SARS-CoV-2 vaccine development. Commentaries have focused on the ethical considerations raised by such models, noting their societal benefits and articulating a range of opinions regarding whether the risk is justified.1-3 The controversy they consider hinges on assumptions about the risk posed by purposeful infection (challenge) of humans with SARS-CoV-2 in a world that lacks a reliable treatment for Covid-19. Both the public health imperative that drives the push for a SARS-CoV-2 CHIM and the demand that the risk be justifiable require a model capable of addressing meritorious questions and delivering scientifically sound answers. On behalf of the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group, we have focused on the practical considerations relevant to the development of a SARS-CoV-2 CHIM and the prerequisites for using such a model.
Source: New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMp2020076?query=featured_home