Meaning: Stop being friendly, end relationships
Example: She GAVE UP all her school friends when she went to university.
Meaning: Stop doing something
Example: I have GIVEN UP trying to help them.
Meaning: Surrender, stop trying
Example: I can't think of the answer; I GIVE UP.
Meaning: Sacrifice or dedicate time, etc, to something
Example: I GAVE UP all my free time to the project.
Meaning: Allow someone to sit in your chair, take your place, etc
Example: I GAVE UP my seat to a pregnant woman.
Meaning: Allow or give away a run while pitching (baseball)
Example: He has GIVEN UP 14 earned runs in 14 innings.
We have 22 phrasal verbs with 'GIVE'