"mess with"?

I have two meanings of "mess with" and which is correct?

(from glee club)

Okay, and no one Messes with celebrities or defaces their pictures.

one meaning is "make a relationship with someone who can possibly harm you", and the other is "harass or bother"

Which is correct? I have no clue.

The second makes more sense.

The first refers to affairs, sexual relationships, etc, that could embarrass or harm someone's career, marriage, etc.

"Mess with"--

--harass, bother, or change