It depends upon the context. In AmE, we use "in" when referring to some particular object (human or otherwise) on the pavement. For example: "John Doe was hit by a car when he was standing in the street begging for money." Or: "Construction was completed on Telegraph Road two months ago but there are still orange traffic cones left in the middle of the street."
Americans say "on" when referring to a location, such as "I live on Main Street" or "The post office is on Evergreen Road."